Dosage
Usual Adult Dose for Plaque Psoriasis
Cream:
-Begin therapy with the 0.05% cream: Apply a thin film once a day in the evening, covering only the psoriatic lesions; if the 0.05% strength is tolerated, the strength may be increased to 0.1%, if needed
Gel:
-Begin therapy with the 0.05% gel: Apply a thin film once a day in the evening covering only the psoriatic lesions to no more than 20% of body surface area; if the 0.05% strength is tolerated, the strength may be increased to 0.1%, if needed
Comments:
-If a bath or shower is taken prior to application, the skin should be dry before applying the cream.
-If emollients are used, apply at least one hour before this drug.
-Avoid applying to unaffected skin because it may be more susceptible to irritation.
Uses:
-The cream (0.05% and 0.1%) is indicated for the topical treatment of plaque psoriasis
-The gel (0.05% and 0.1%) is indicated for the topical treatment of stable plaque psoriasis of up to 20% body surface area involvement
Usual Adult Dose for Acne
0.1% cream: Apply a thin layer once daily in the evening to skin areas where acne lesions appear; use enough to cover the entire affected area
0.1% gel: Apply a thin film once daily in the evening to skin areas where acne lesions appear; use enough to cover the entire affected area; use beyond 12 weeks has not been studied
Comments:
-Cleanse the face gently and dry before application.
-Use sunscreen and wear protective clothing while using this drug.
Uses:
-The 0.1% cream is indicated for the topical treatment of acne vulgaris
-The 0.1% gel is indicated for the topical treatment of facial acne vulgaris of mild to moderate severity
Usual Pediatric Dose for Acne
12 years or older:
0.1% cream: Apply a thin layer once daily in the evening to skin areas where acne lesions appear; use enough to cover the entire affected area
12 years or older:
0.1% gel: Apply a thin film once daily in the evening to skin areas where acne lesions appear; use enough to cover the entire affected area; use beyond 12 weeks has not been studied
Comments:
-Cleanse the face gently and dry before application.
-Use sunscreen and wear protective clothing while using this drug.
Uses:
-The 0.1% cream is indicated for the topical treatment of acne vulgaris
-The 0.1% gel is indicated for the topical treatment of facial acne vulgaris of mild to moderate severity
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
Safety and efficacy have not been established in patients younger than 18 years for psoriasis.
Safety and efficacy have not been established in patients younger than 12 years for acne.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
General:
-For topical use only.
-Not for ophthalmic, oral, or intravaginal use.
-Patients should be advised to wash their hands after application of the gel to avoid accidental transfer to the eyes.
-If contact with eyes or mucous membranes occurs, rinse thoroughly with water.
-Wash hands thoroughly after application.
-If skin irritation develops, interrupt therapy.
-Advise patients to avoid excessive exposure to UV light (e.g., sunlight, use of a solarium, PUVA, or UVB) during therapy.
-This drug should be administered with caution if the patient is also taking drugs known to be photosensitizers (e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides) because of the increased possibility of augmented photosensitivity.