Allergy to penicillins

Previous history of cholestatic jaundice/hepatic dysfunction associated with amoxicillin/clavulanate

Extended release: Hemodialysis patients and severe renal impairment (CrCl <30 mL/min)

Allergy to cephalosporins, carbapenems

Different tablets are not interchangeable, because ratios of amoxicillin to clavulanate are different

Extended release tablets not for use in renal impairment (CrCl <30 mL/min)

Incidence of diarrhea is higher than with amoxicillin alone

Unknown safety and efficacy of extended-release tablets in patients <16 years old

Risk of Clostridium difficile-associated diarrhea (CDAD); consider in patients who present with diarrhea after antibiotic use; CDAD has been known to occur over 2 months after antibiotic therapy; if suspected, discontinue drug immediately and administer appropriate fluid/electrolyte therapy, protein supplementation, and C difficile antibiotic treatment

Risk of bacterial or fungal superinfections; if suspected, discontinue drug immediately and administer appropriate therapy

High percentage of patients with mononucleosis reported to develop rash during therapy; ampicillin-class antibiotics not recommended in these patients

Use caution in hepatic impairment; hypatic dysfunction (rare) is more common in elderly and/or males and prolonged therapy may increase risk; may occur after completing therapy