Rotacysteine

Acetylcysteine 20%

Dosing & Uses

Adult

Dosage Forms & Strengths

nebulizer solution

  • 10%
  • 20%

Pulmonary Disease

Facilitation of expectoration via mucolysis

5-10 mL of 10% or 20% solution by nebulization q6-8hr PRN

Diagnostic Bronchography

1-2 mL of 20% solution or 2-4 mL of 10% solution administered 2-3 times by nebulization or by intratracheal instillation before procedure

Acetaminophen Overdose

See separate drug monograph, acetylcysteine (antidote)

Acute Hepatic Failure (Orphan)

Not FDA-approved for orphan designation

Orphan sponsor

  • Cumberland Pharmaceuticals, Inc, 2525 West End Ave, Suite 950, Nashville, TN 37203

Contrast Agent-Associated Nephrotoxicity (Off-label)

Prevention

600 mg PO q12hr for 2 days on day before and day of contrast agent administration

Keratoconjunctivitis Sicca (Off-label)

1 drop of 10% solution in eye(s) q6-8hr

Dosing Considerations

Direct instillation: 1-2 mL of 10% or 20% solution q1hr PRN

Routine nursing care of patients with tracheotomy: 1-2 mL of 10% or 20% solution q1-4hr by direct instillation into tracheotomy

Instillation into segment of bronchopulmonary tree via small plastic catheter into trachea (under local anesthesia and direct vision): 2-5 mL of 20% solution via syringe connected to catheter

Instillation via percutaneous intratracheal catheter: 1-2 mL of 20% solution or 2-4 mL of 10% solution q1-4hr via syringe connected to catheter

Administration

Administer aerosolized bronchodilator 10-15 minutes before administering acetylcysteine via nebulization

Nebulizer solution may also be administered PO

Pediatric

Dosage Forms & Strengths
nebulizer solution

  • 10%
  • 20%
Pulmonary Disease
Facilitation of expectoration via mucolysis
1-11 months: 1-2 mL of 20% solution or 2-4 mL of 10% solution by nebulization q6-8hr PRN
1-11 years: 3-5 mL of 20% solution or 6-10 mL of 10% solution by nebulization q6-8hr PRN
>12 years: 5-10 mL of 10% or 20% solution by nebulization q6-8hr PRN

Acetaminophen Overdose
See separate drug monograph, acetylcysteine (antidote)

Ototoxicity Caused by Platinum-Based Chemotherapy (Orphan)
Prevention of ototoxicity caused by platinum-based chemotherapeutic agents used to treat pediatric cancers
Not FDA-approved for orphan indication
Orphan sponsor

  • Galephar Pharmaceutical Research, Inc, Road 198, No. 100 km. 14.7, Juncos Industrial Park, Juncos 00777-3873, Puerto Rico
Keratoconjunctivitis Sicca (Off-label)
1 drop of 10% solution in eye(s) q6-8hr

Dosing Considerations
Direct instillation: 1-2 mL of 10% or 20% solution q1hr PRN
Routine nursing care of patients with tracheotomy: 1-2 mL of 10% or 20% solution q1-4hr by direct instillation into tracheotomy
Instillation via percutaneous intratracheal catheter: 1-2 mL of 20% solution or 2-4 mL of 10% solution q1-4hr via syringe connected to catheter

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