Adverse Effects
More than 10%
Fatigue (8-96%)
Fever (34-94%)
Neutropenia (92%)
Flu-like syndrome (79%)
Myalgia (28-75%)
Anorexia (1-69%)
Leukopenia (68%)
Nausea (17-66%)
Transaminases increased (13-63%)
Weakness (63%)
Headache (21-62%)
Chills (54%)
Diarrhea (2-45%)
Rigors (42%)
Depression (up to 40% of pts), suicidal ideation/ attempts, suicide
Alopecia (38%)
Dyspnea (34%)
Somnolence (33%)
Vomiting (2-32%)
Anemia (32%)
Cough (31%)
Pharyngitis (31%)
Chest pain (28%)
Xerostomia (28%)
Rash (25%)
Dizziness (24%)
Taste alteration (24%)
Abdominal pain (1-23%)
Irritability (22%)
Sinusitis (21%)
Skeletal pain (21%)
Diaphoresisi (1-21%)
Paresthesias (1-21%)
Arthralgia/back pain (19%)
Pain (18%)
Moniliasis (17%)
Thrombocytopenia (15%)
Amnesia (14%)
Constipation (14%)
Gingivitis (14%)
Impaired concentration (14%)
Malaise (14%)
Weight loss (1-13%)
Amenorrhea (12%)
BUN increased (12%)
Confusion (12%)
Insomnia (12%)
Iruritus (11%)
1-10%
Bronchitis (10%)
Dry skin (10%)
Edema (10%)
Hypoestheisa (10%)
Loose stools (10%)
Nasal congestion (10%)
Polyuria (10%)
Anxiety (9%)
Hypertension (9%)
Dermatitis (8%)
Dyspepsia (8%)
Vertigo (8%)
Agitation (7%)
Infection (7%)
SCr increased (6%)
Herpes virus infections (5%)
UTI (5%)
Less than 1%
Acute hypersensitivity reactions; exacerbation of preexisting psoriasis & sarcoidosis
Myelosuppression, thyroid dysfunction, hepatotox., pulmonary infiltrates, retinal hemorrhage
Severe cytopenias incl aplastic anemia
Autoimmune dz, DM/hyperglycemia (rare)
Posmarketing reports
Pulmonary fibrosis
Hepatitis B virus reactivation in HCV/HBV co-infected patients
Pericarditis