Minipress

Prazosin

Dosing & Uses

Dosage Forms & Strengths

capsule

• 1 mg
  
• 2 mg
  
• 5 mg
  

Hypertension

Initial: 1 mg PO q8-12hr

Maintenance: 6-15 mg/day divided 2 or 3 times daily; alternatively, 1-5 mg PO BID; may increase dose to 20 mg/day in divided doses; some patients may benefit from up to 40 mg/day in divided doses

PTSD-Related Nightmares & Sleep Disruption (Off-label)

Initial: 1 mg PO qHS

Maintenance: 1 mg PO qHS initially; may increase dose to 2 mg qHS; adjust dose based on response and tolerability in 1-2 mg increments q7days; not to exceed 15 mg/day

Benign Prostate Hypertrophy (Off-label)

Initial: 0.5 mg PO q12hr

Maintenance: 2 mg PO q12hr

Raynaud Phenomenon (Off-label)

0.5-1 mg PO qDay (HS) or 0.5 mg PO BID; adjust dose based on response and tolerability up to 12 mg/day divided BID/TID

Administration

Give first dose and subsequent increases at bedtime to avoid syncope

Okay with food

Pediatric

Dosage Forms & Strengths

capsule

• 1 mg
  
• 2 mg
  
• 5 mg
  

Hypertension (Off-label)

Initial: 0.05-0.1 mg/kg/day PO divided q8hr 

Titrate to 0.5 mg/kg/day; not to exceed 20 mg/day

Administration

Okay with food