Lipitor 40mg Tablet

Atorvastatin 40mg

Dosing & Uses
Adult

Dosage Forms & Strengths

tablet

  • 10 mg
  • 20 mg
  • 40 mg
  • 80 mg

Hyperlipidemia

Primary hypercholesterolemia and mixed dyslipidemia

  • Indicated as an adjunct to diet for treatment of elevated total-C, Apo B, and TG levels and to increase HDL-C in patients with primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson type IIa and IIb)
  • 10-20 mg PO qDay initially
  • Starting dose in patients requiring larger LDL-C reduction (ie, >45%): 40 mg PO qDay
  • Maintenance: 10-80 mg PO qDay
  • After initiation and/or upon dose titration, check lipid levels after 2-4 weeks and adjust dose accordingly

Hypertriglyceridemia

  • Adjunct to diet for elevated TG levels (Fredrickson type IV)
  • 10 mg PO qDay initially
  • Maintenance: 10-80 mg PO qDay maintenance
  • After initiation and/or upon dose titration, check lipid levels after 2-4 weeks and adjust dose accordingly

Primary dysbetalipoproteinemia

  • Dysbetalipoproteinemia (Fredrickson type III) in patient with inadequate response to diet
  • Maintenance: 10-80 mg PO qDay
  • After initiation and/or upon dose titration, check lipid levels after 2-4 weeks and adjust dose accordingly

Homozygous familial hypercholesterolemia

  • Reduction of total-C and LDL-C in HoFH as an adjunct to other lip-lowering treatments (eg, LDL apheresis) or if such treatments are unavailable
  • 10-80 mg PO qDay

Cardiovascular Disease Prevention

10-80 mg PO qDay

Indications

  • Reduction of risk of stroke and heart attack in type 2 diabetes patients without evidence of heart disease but with other CV risk factors
  • Reduction of risk of stroke, heart attack, and revascularization procedures in patients without evidence of coronary heart disease (CHD) but with multiple risk factors other than diabetes (eg, smoking, HTN, low HDL-C, family history of early CHD)
  • Patients with CHD, to reduce risks of MI, stroke, revascularization procedures, hospitalization for CHF, and angina

Dosage Considerations

Coadministration with other drugs

  • Bile acid sequestrant: Administer atorvastatin/ezetimibe ≥2 hr before or ≥4 hr after administering bile acid sequestrant
  • Cyclosporine, tipranavir plus ritonavir, telaprevir, gemfibrozil: Avoid coadministration with atorvastatin (increased risk of rhabdomyolysis)
  • Lopinavir plus ritonavir: Use lowest dose of atorvastatin necessary
  • Clarithromycin, itraconazole, saquinavir plus ritonavir, darunavir plus ritonavir, fosamprenavir: Do not exceed atorvastatin dose of 20 mg/day
  • Nelfinavir, boceprevir: Do not exceed atorvastatin dose of 40 mg/day

Overdose management

  • Generally considered safe in acute overdose, although not formally studied
  • Adverse drug reactions from overdose may include peripheral neuropathy, diarrhea, increased K+, myopathy, rhabdomyolysis, acute renal failure, elevated LFTs, eye lens opacities
  • Treatment is supportive
Pediatric

Dosage Forms & Strengths

tablet

  • 10 mg
  • 20 mg
  • 40 mg
  • 80 mg

Heterozygous Familial Hypercholesterolemia

Indicated as an adjunct to diet to reduce total-C, LDL-C, and apo B levels in boys and postmenarchal girls aged 10-17 years with HeFH who have an inadequate response to diet alone (ie, LDL-C remains ≥190 mg/dL or LDL-C remains ≥160 mg/dL and there is positive family history or early CV disease or 2 or more other CVD risk factors present)

<10 years: Safety and efficacy not established

≥10 years: Initially, 10 mg PO qDay; titrate at 4-week intervals; not to exceed 20 mg PO qDay

Homozygous Familial Hypercholesterolemia (Off-label)

<10 years: Safety and efficacy not established

≥10 years: 10-40 mg PO qDay