Histazine 10 mg

Cetirizine 10 mg

Pharmacology
Mechanism of Action
Histamine H1-receptor antagonist; competes with histamine on effector cells in the gastrointestinal tract, blood vessels and respiratory tract

Absorption
Peak plasma concentration: 114 ng/mL
Peak serum time: 1 hr
Duration: >24 hr ( suppression of skin wheal and flare reactions

Distribution
Protein bound: 93%
Vd: 0.56 L/kg

Metabolism
Metabolism: Liver; low first pass
Limited extent by oxidative O-dealkylation to inactive metabolite

Elimination
Half-life: 7.9hr
Excretion: Urine (70%); feces (10%)

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