Patients who suffer from asthma, hay fever, inflammation of nasal membranes (nasal polyps), or chronic infections of the respiratory tract are more susceptible to hypersensitivity reactions, therefore, must take special precautions (availability of equipment first aid). Is imperative and constant medical supervision in patients with a history of gastric or intestinal gastrointestinal disturbances, hypertension and / or impaired cardiac, gastrointestinal inflammation, ulcerative colitis, Crohn’s disease, hepatic or renal dysfunction, patients treated with diuretics and the elderly. Special attention should be paid to patients with impaired cardiac or renal function, those who are being treated with diuretics and postoperative patients where major surgery, the importance of prostaglandins for maintaining renal blood flow . In these cases be administered under special precautions. In exceptional cases under the medication is noted the appearance of ulcer or gastrointestinal bleeding, should be discontinued. Special precautions should be taken in elderly patients, for clinical reasons involved. During prolonged treatment is recommended to monitor blood count, liver function and kidney. Effects on ability to drive vehicles and / or operate machinery: This medicine can cause changes in the responsiveness, even when administered as prescribed. These changes may influence the ability to drive and operate machinery. These difficulties are enhanced by concomitant intake of alcohol. pregnancy and lactation: only be given during pregnancy when strictly necessary and only use the lowest effective dose possible. Like other inhibitors of prostaglandin synthetase, the above applies particularly in the last three months of pregnancy (for the potential development of uterine inertia and / or premature closure of the arterial duct). After oral doses of 50 mg, given every eight hours, the active substance passes into breast milk in quantities so small that no undesirable effects are expected in the infant.