Occasional: epigastric pain, gastrointestinal disturbances such as nausea, vomiting, diarrhea, abdominal cramps, dyspepsia, flatulence, anorexia. Rare: gastrointestinal bleeding (hematemesis, melena, bloody diarrhea), stomach or intestinal ulcers with or without bleeding or perforation. Isolated cases: aphthous stomatitis, glossitis, oesophageal lesions, intestinal stenosis, diaphragmatic lower colon disturbances, such as non-specific haemorrhagic colitis and exacerbation of ulcerative colitis or Crohn’s disease, constipation and pancreatitis. Central nervous system: Occasional: headache, dizziness or vertigo. Rare: drowsiness. Isolated cases: disturbances of sensation, including paresthesia, memory disturbances, insomnia, irritability, seizures, depression, anxiety, nightmares, tremor, psychotic reactions, aseptic meningitis. Sensory Organs: Isolated cases: disturbances of vision (blurred vision, diplopia), impaired hearing, tinnitus and taste disturbances. Skin: Uncommon: rash. Rare: urticaria. Isolated cases: erythroderma (exfoliative dermatitis), hair loss, photosensitivity reaction, purpura, including purpura allergic rash with blisters, eczema, erythema multiforme, Stevens-Johnson syndrome, Lyell syndrome (acute toxic epidermolysis). Urogenital system: Rare: edema. Isolated cases: acute renal failure, urinary disturbances, such as hematuria and proteinuria, interstitial nephritis, nephrotic syndrome, papillary necrosis. Liver: Occasional: elevated serum aminotransferase enzymes. Rare: hepatitis, with or without jaundice. Isolated cases: fulminant hepatitis. Blood: Isolated cases: thrombocytopenia, leukopenia, anemia (hemolytic and aplastic), agranulocytosis. Hypersensitivity: rare cases hypersensitivity reactions such as asthma, systemic reactions, anaphylactic / anaphylactoid reactions, including hypotension. Isolated cases: vasculitis, pneumonia. Cardiovascular system: Isolated cases: palpitation, chest pain, hypertension, congestive heart failure.