Doxazosin
Dosage Forms & Strengths
tablet
tablet, extended release
Hypertension
1 mg PO qDay in AM or PM; may titrate by doubling daily dose up to 16 mg qDay based on blood pressure response; usual dosage range is 1-2 mg qDay; if therapy is discontinued for several days, initiate dose at 1 mg qDay and titrate using initial dosing regimen
Extended release: Not indicated for hypertension
Benign Prostatic Hyperplasia
Immediate release: 1 mg PO qDay; may titrate by doubling daily dose at 1-2 week intervals to maximum 8 mg/day
If therapy is discontinued for several days, initiate dose at 1 mg qDay and titrate using initial dosing regimen
Extended release: 4 mg PO qDay; may titrate based on response and tolerability every 3-4 weeks to 8 mg PO qDay
If therapy is discontinued for several days, initiate dose at 1 mg qDay and titrate using initial dosing regimen
Dosing Modifications
Hepatic impairment: Use with caution in mild-to-moderate hepatic dysfunction; do not use in severe impairment
Renal impairment: Labeling from manufacturer does not provide dosage adjustment information
Dosing Considerations
Give first dose and increase at bedtime to avoid syncope
Pediatric
Dosage Forms & Strengths
tablet
Hypertension (Off-label)
Immediate release: 1-4 mg PO once daily in AM or PM
Geriatric
Hypertension
Avoid use for hypertension; high risk of orthostatic hypotension (Beers criteria); if used, lower initial dosages and gradual adjustments are recommended
Immediate release: 0.5-16 mg PO once daily in AM or PM
Extended release: Not indicated for hypertension
Benign Prostatic Hyperplasia
Immediate release: 1-8 mg/day PO
Extended release: 4 mg/day PO initially at breakfast; may be increased to no more than 8 mg/day PO