Dermozol cort

Hydrocortisone 1%, miconazole 2%

Pharmacokinetics

Miconazole does not produce detectable blood levels after topical application.

Depending on the location and type of infection, hydro-cortisone penetrates well into the skin and is partially absorbed.

More than 90% of the absorbed fraction bound to plasma proteins.

The metabolism takes place in the liver tissues and the metabolites are excreted with the urine, mostly as glucuronides, together with a very small fraction of unchanged hydrocortisone.

The biological half-life is about 100 minutes.

References