Colchicine 500 mcgm

Colchicine 500 mcgm

Coadministration with P-gp or strong CY3A4 inhibitors in patients with hepatic or renal impairment; life-threatening and fatal colchicine toxicity has been reported with therapeutic dosages

Long term use is established for FMF, but safety and efficacy of repeat treatment in gout flares has not been evaluated
Not to be used to treat pain from other causes; drug is not analgesic
Must be kept out of reach of children; fatal overdoses have been reported
Blood dyscrasias (eg, leukopenia, myelosuppression, thrombocytopenia, pancytopenia, granulocytopenia, aplastic anemia) have been reported at therapeutic dosages
Coadministration with P-gp and strong CYP3A4 inhibitors may warrant dosage reduction or interruption of therapy
Rhabdomyolysis and neuromuscular toxicity have been reported with long-term treatment at therapeutic dosages; increased risk with renal dysfunction, elderly patients, concomitant therapy with myotoxic drugs; symptoms generally resolve within 1 week to few months upon discontinuance
Acute gout: Dosages >1.8 mg/day provide no additional efficacy
Dose reduction recommended in patients who develop gastrointestinal symptoms including anorexia, diarrhea, vomiting, or nausea due to the therapy
Clearance is decreased in renal and hepatic impairment; monitor for toxicity and adjust dose if necessary
Use with caution in the elderly; consider adjusting dose

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