Colchicine 500 mcgm

Colchicine 500 mcgm

Pharmacology
Mechanism of Action
Gout: Disruption of cytoskeletal functions through inhibition of β-tubulin polymerization into microtubules; this prevents activation, degranulation, and migration of neutrophils thought to mediate some gout symptoms
FMF: Mechanism not established; may interfere with intracellular assembly of inflammasome complex present in neutrophils and monocytes, which mediates activation of interleukin-1β

Absorption
Bioavailability: 45%
Onset: 18-24 hr
Time to peak effect: 48-72 hr
Peak plasma concentration: 6.2-6.8 ng/mL

Distribution
Protein bound: 34-44%
Vd: 5-8 L/kg

Metabolism
Metabolized by P-gp and CYP3A4
Metabolites: Demethylated to 2 primary metabolites and 1 minor metabolite

Elimination
Half-life: 26.6-31.2 hr
Dialyzable: No (hemodialysis)
Excretion: Feces, urine (65%)
References