Cloxide

Clidinium bromide 2.5 mg, chlordiazepoxide 5 mg

Dosing & Uses

Dosage Forms & Strengths

chlordiazepoxide/clidinium

capsule

• 5 mg/2.5 mg
  

Peptic Ulcer, IBS, & Enterocolitis

1-2 cap PO q6-8hr ac and hs

Possibly effective

• Based on a review by the National Academy of Sciences – National Research Council and/or other information, FDA as classified the indications as follows:
  
• “Possibly” effective: as adjunctive therapy in the treatment of peptic ulcer and in the treatment of the irritable bowel syndrome (irritable colon, spastic colon, mucous colitis), and acute enterocolitis
  
• Final classification of the less-than-effective indications requires further investigation
  

Pediatric

Safety and efficacy not established

Geriatric

Avoid; high incidence of anticholinergic effects and uncertain effectiveness; avoid except in short-term situations to decrease secretions (Beers Criteria)

Use smallest effective dose

Not to exceed 2 capsules PO per day initially; may increase gradually as needed and tolerated

Ataxia, oversedation, or confusion may occur more frequently in elderly patients